Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

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Chemical Name:Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester
CAS No.:871102-20-4
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:

Synonyms:Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

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Chemical Property of Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

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Technology Process of Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

There total 3 articles about Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871102-18-0
Formic acid 2-[(R)-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

: 98-88-4
benzoyl chloride

: 871102-20-4
Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

: 871102-22-6
Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

Guidance literature:: With trifluorormethanesulfonic acid; In benzene; at 20 ℃; for 10h;
DOI:10.1016/j.tet.2005.08.091

Reference yield:

: 71046-46-3
6-azaspiro<4.5>decane-1,7-dione

: 871102-20-4
Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 82 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 89 percent / triflic acid / 20 °C

3.1: 84 mg / triflic acid / benzene / 10 h / 20 °C

With trifluorormethanesulfonic acid; tert.-butyl lithium; In tetrahydrofuran; benzene;
DOI:10.1016/j.tet.2005.08.091

Reference yield:

: (1R,5R)-1-Hydroxy-1-isopropenyl-6-aza-spiro[4.5]decan-7-one

: 871102-20-4
Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / triflic acid / 20 °C

2: 84 mg / triflic acid / benzene / 10 h / 20 °C

With trifluorormethanesulfonic acid; In benzene;
DOI:10.1016/j.tet.2005.08.091