6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

Base Information

• Chemical Name: 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine
• CAS No.: 244141-28-4
• Molecular Formula: C₃₀H₂₄ClF₃N₄O₅S
• Molecular Weight: 645.059
• Mol file: 244141-28-4.mol

Synonyms:6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

Chemical Property of 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

There total 8 articles about 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethanesulfonic acid anhydride (1025373-45-8) + 6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244140-86-1) → 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244141-28-4)

Guidance literature:

With pyridine; ammonium chloride; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244140-86-1) → 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244141-28-4)

Guidance literature:

In pyridine; dichloromethane;

DOI:10.1081/NCN-100002490

Reference yield:

6-chloro-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purine (6982-08-7) → 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244141-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 2,4,6-collidine / acetonitrile

2: pyridine / CH₂Cl₂

With pyridine; 2,4,6-trimethyl-pyridine; In dichloromethane; acetonitrile;

DOI:10.1081/NCN-120021951

upstream raw materials:

trifluoromethylsulfonic anhydride

6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one

6-chloro-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

Downstream raw materials:

6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine

9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine

iodenosine