6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine

Base Information

• Chemical Name: 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine
• CAS No.: 244140-87-2
• Molecular Formula: C₂₉H₂₄ClFN₄O₂
• Molecular Weight: 514.987

Synonyms:6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine

Chemical Property of 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine

Chemical Property:

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Technology Process of 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine

There total 12 articles about 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244141-28-4) → 6-chloro-9-[2,3-dideoxy-2,3-didehydro-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine + 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine (244140-87-2)

Guidance literature:

With triethylamine tris(hydrogen fluoride); triethylamine; In toluene;

DOI:10.1081/NCN-120021951

Reference yield: 62.4%

6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244140-86-1) → 6-chloro-9-[2,3-dideoxy-2,3-didehydro-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine + 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine (244140-87-2)

Guidance literature:

With Nonafluorobutanesulfonyl fluoride; N,N-dimethyl-cyclohexanamine; at 50 ℃; for 23h;

DOI:10.1081/NCN-120016572

Reference yield: 57.8%

triethylamine tris(hydrogen fluoride) (73602-61-6,23588-89-8,29585-72-6,94527-74-9) + 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine (244141-28-4) → 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine (244140-87-2)

Guidance literature:

With triethylamine; In methanol; toluene;

upstream raw materials:

6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

6-chloro-9-[3-deoxy-2-O-(sulfurylimidazolyl)-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine

9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one

Downstream raw materials:

9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine

iodenosine

9-[2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl]-1,6-dihydro-6-oxo-9H-purine

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