1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Base Information

Chemical Name:1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea
CAS No.:1195173-44-4
Molecular Formula:C₂₅H₂₇N₃O₂
Molecular Weight:401.508
Hs Code.:

Synonyms:1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

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Chemical Property of 1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

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Technology Process of 1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

There total 12 articles about 1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195179-05-5
1-(4-(2-methylpyridin-4-yl)phenyl)-3-(4-oxo-1-phenylcyclohexyl)urea

: 1195173-44-4
1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 94112-58-0
4-hydroxy-4-phenyl-cyclohexanone ethylene ketal

: 1195173-44-4
1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

2.1: hydrogen / 10% Pd/C / ethanol / 20 °C

3.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

3.2: 20 °C

4.1: water; toluene-4-sulfonic acid / acetone / 4 h / 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; sodium azide; water; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; 10% Pd/C; In tetrahydrofuran; ethanol; dichloromethane; acetone;

Reference yield:

: 1195178-97-2
8-azido-8-phenyl-1,4-dioxaspiro[4.5]decane

: 1195173-44-4
1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 10% Pd/C / ethanol / 20 °C

2.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

2.2: 20 °C

3.1: water; toluene-4-sulfonic acid / acetone / 4 h / 20 °C

4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; water; hydrogen; toluene-4-sulfonic acid; 10% Pd/C; In tetrahydrofuran; ethanol; acetone;