94112-58-0

Basic information

• Product Name: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL
• Synonyms: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL
• CAS NO: 94112-58-0
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.29
• Mol File: 94112-58-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 384.5°Cat760mmHg
• Flash Point: 186.4°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL(94112-58-0)
• EPA Substance Registry System: 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL(94112-58-0)

Safety Data

• Hazardous Substances Data: 94112-58-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H18O3/c15-13(12-4-2-1-3-5-12)6-8-14(9-7-13)16-10-11-17-14/h1-5,15H,6-11H2

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 108-86-1 bromobenzene 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 76-84-6 triphenylmethyl alcohol 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 51171-73-4 4-hydroxy-4-phenylcyclohexanone 
• 937648-16-3 2-amino-6-phenyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 1297474-38-4 C₁₅H₁₂N₂OS 
• 1297474-47-5 C₂₇H₂₂N₂O₅S 
• 1297474-13-5 C₂₅H₁₈N₂O₅S 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 51171-78-9 4-amino-1-phenylcyclohexan-1-ol 
• 51171-78-9 4-amino-1-phenylcyclohexan-1-ol 
• 51171-77-8 4-Phenyl-4-hydroxycyclohexanon-oxim 
• 1195179-01-1 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea 
• 1195173-47-7 1-(4,4-difluoro-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea 
• 1195173-44-4 1-(4-hydroxy-1-phenylcyclohexyl)-3-(4-(2-methylpyridin-4-yl)phenyl)urea 
• 1195179-05-5 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(4-oxo-1-phenylcyclohexyl)urea 
• 79741-43-8 8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine 

Relevant articles and documents

Shuttle arylation by Rh(I) catalyzed reversible carbon–carbon bond activation of unstrained alcohols

The advent of transfer hydrogenation and borrowing hydrogen reactions paved the way to manipulate simple alcohols in previously unthinkable manners and circumvented the need for hydrogen gas. Analogously, transfer hydrocarbylation could greatly increase the versatility of tertiary alcohols. However, this reaction remains unexplored because of the challenges associated with the catalytic cleavage of unactivated C–C bonds. Herein, we report a rhodium(I)-catalyzed shuttle arylation cleaving the C(sp2)–C(sp3) bond in unstrained triaryl alcohols via a redox-neutral β-carbon elimination mechanism. A selective transfer hydrocarbylation of substituted (hetero)aryl groups from tertiary alcohols to ketones was realized, employing benign alcohols as latent C-nucleophiles. All preliminary mechanistic experiments support a reversible β-carbon elimination/migratory insertion mechanism. In a broader context, this novel reactivity offers a new platform for the manipulation of tertiary alcohols in catalysis.

NHC-coordinated palladacycle catalyzed 1,2-addition of arylboronates to unactivated ketones

Palladium catalyzed intermolecular 1,2-addition of arylboronate to unactivated ketone was investigated. NHC-coordinated palladacycle 4c exhibited catalytic activity for the reactions and provided the corresponding tertiary alcohols and γ,γ-disubstituted γ-lactones in good to excellent yields.

Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method

Herein, we report the discovery of the first potent and selective inhibitor of TRPV6, a calcium channel overexpressed in breast and prostate cancer, and its use to test the effect of blocking TRPV6-mediated Ca2+-influx on cell growth. The inhib