1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

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Chemical Name:1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide
CAS No.:1561958-70-0
Molecular Formula:C₃₃H₄₈N₂O₃
Molecular Weight:520.756
Hs Code.:

Synonyms:1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

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Chemical Property of 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

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Technology Process of 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

There total 9 articles about 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 38041-19-9
4-aminotetrahydropyran

: 1561965-08-9
1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-1H-pyrrole-3-carboxylic acid

: 1561958-70-0
1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: With HATU; In N,N-dimethyl-formamide; at 40 ℃; for 1h;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561958-70-0
1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / Reflux; Inert atmosphere

2.1: tetrahydrofuran / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

4.1: potassium tert-butylate; water / dimethyl sulfoxide / 1.5 h / 90 °C

5.1: HATU / N,N-dimethyl-formamide / 1 h / 40 °C

With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium tert-butylate; water; sodium hydride; HATU; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1561964-55-3
ethyl 1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(hydroxy)methyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561958-70-0
1-(3-(tert-butyl)-5-(1-methylcyclopropyl)phenyl)-5-(cyclohexyl(methoxy)methyl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: potassium tert-butylate; water / dimethyl sulfoxide / 1.5 h / 90 °C

3.1: HATU / N,N-dimethyl-formamide / 1 h / 40 °C

With potassium tert-butylate; water; sodium hydride; HATU; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;