4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

Base Information

Chemical Name:4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)
CAS No.:1380450-03-2
Molecular Formula:C₂₆H₂₁BrO₃
Molecular Weight:461.355
Hs Code.:

Synonyms:4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

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Chemical Property of 4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

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Technology Process of 4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

There total 5 articles about 4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1380449-99-9
1-(2-bromoethoxy)-2,3-diiodobenzene

: 768-60-5
4-methoxyphenylacetylen

: 1380450-03-2
4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 8h;
DOI:10.1021/ja3023626

Reference yield:

: 408340-16-9
2,3-diiodophenol

: 1380450-03-2
4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

Guidance literature:: Multi-step reaction with 2 steps

1.1: 18-crown-6 ether; potassium carbonate / acetone / Reflux

1.2: Reflux

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 18-crown-6 ether; potassium carbonate; triethylamine; In acetone; 2.1: Sonogashira coupling;
DOI:10.1021/ja3023626

Reference yield:

: 863870-73-9
O-3-iodophenyl N,N-diethylcarbamate

: 1380450-03-2
4,4'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(methoxybenzene)

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium hydroxide / ethanol / 8 h / Reflux

3.1: 18-crown-6 ether; potassium carbonate / acetone / Reflux

3.2: Reflux

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 18-crown-6 ether; potassium carbonate; triethylamine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; acetone; 4.1: Sonogashira coupling;
DOI:10.1021/ja3023626