N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

Base Information

Chemical Name:N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide
CAS No.:104716-80-5
Molecular Formula:C₃₃H₃₄FNO₆
Molecular Weight:559.634
Hs Code.:

Synonyms:N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

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Chemical Property of N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

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Technology Process of N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

There total 6 articles about N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 104716-81-6
2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethylamine

: 104716-80-5
N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

Guidance literature:: In toluene; for 72h; Heating;
DOI:10.1021/jm00384a015

Reference yield:

: 104716-77-0
3,4-bis(benzyloxy)-5-fluorobenzyl cyanide

: 104716-80-5
N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: BH₃*THF / tetrahydrofuran / 18 h / Heating

2: 75 percent / toluene / 72 h / Heating

With borane-THF; In tetrahydrofuran; toluene;
DOI:10.1021/jm00384a015

Reference yield:

: 103905-49-3
5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene

: 104716-80-5
N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) MeI / 1.) CHCl₃, 25 deg C, 18 h, 2.) DMSO, 25 deg C, 7 h

2: 90.1 percent / BBr₃ / CH₂Cl₂ / 18 h / 25 °C

3: 80 percent / K₂CO₃, KI / acetone / 4 h / Heating

4: BH₃*THF / tetrahydrofuran / 18 h / Heating

5: 75 percent / toluene / 72 h / Heating

With borane-THF; boron tribromide; potassium carbonate; potassium iodide; methyl iodide; In tetrahydrofuran; dichloromethane; acetone; toluene;
DOI:10.1021/jm00384a015