(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Base Information

Chemical Name:(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate
CAS No.:1614253-55-2
Molecular Formula:C₃₁H₃₄N₂O₉
Molecular Weight:578.619
Hs Code.:

Synonyms:(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

There total 5 articles about (S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1614253-54-1
5-iodo-2-methyloxymethyloxy-4-nitrobenzyl alcohol

: 282734-33-2
(2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester

: 1614253-55-2
(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Guidance literature:: (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester; With iodine; zinc; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

5-iodo-2-methyloxymethyloxy-4-nitrobenzyl alcohol; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 137832-56-5
methyl 4-amino-5-iodo-2-methoxybenzoate

: 1614253-55-2
(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium iodide; tert.-butylhydroperoxide / acetonitrile; water / 110 °C / Autoclave

2.1: boron tribromide / dichloromethane / 0.5 h / -78 °C

3.1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -35 °C / Inert atmosphere

5.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; tetrabutyl-ammonium chloride; iodine; boron tribromide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc; In dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1614253-52-9
methyl 5-iodo-2-hydroxy-4-nitrobenzoate

: 1614253-55-2
(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -35 °C / Inert atmosphere

3.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C / Inert atmosphere

With tetrabutyl-ammonium chloride; iodine; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; N,N-dimethyl-formamide; toluene;