2-methoxy-3-phenylpropanal

Base Information

• Chemical Name: 2-methoxy-3-phenylpropanal
• CAS No.: 256229-07-9
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Mol file: 256229-07-9.mol

Synonyms:2-methoxy-3-phenylpropanal

Chemical Property of 2-methoxy-3-phenylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-methoxy-3-phenylpropanal

There total 5 articles about 2-methoxy-3-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methoxy-3-phenylpropanol (221908-50-5) → 2-methoxy-3-phenylpropanal (256229-07-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - -20 ℃; for 0.666667h;

DOI:10.1016/S0957-4166(99)00427-9

Reference yield:

C13H18OS2 (1450842-94-0) → 2-methoxy-3-phenylpropanal (256229-07-9)

Guidance literature:

With N-Bromosuccinimide; barium carbonate; In acetone; at 0 - 30 ℃;

DOI:10.1039/c3ob40685g

Reference yield:

phenyllactic acid (828-01-3) → 2-methoxy-3-phenylpropanal (256229-07-9)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl (gas)

2: NaH

3: LiAlH₄ / tetrahydrofuran

4: 90 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 0.67 h / -60 - -20 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1: Esterification / 2: Alkylation / 3: Reduction / 4: Oxidation;

DOI:10.1016/S0957-4166(99)00427-9

upstream raw materials:

2-methoxy-3-phenylpropanol

phenyllactic acid

methyl 2-hydroxy-3-phenylpropanoate

methyl 2-methoxy-3-phenylpropanoate

Downstream raw materials:

N-(4-methylphenyl)formamide

benzeneacetic acid methyl ester

Refernces

• 1、 Roda, Gabriella,Riva, Sergio,Danieli, Bruno. "Almond oxynitrilase-catalyzed transformation of aldehydes is strongly influenced by naphthyl and alkoxy substituents". . p. 3939 - 3949. Retrieved 2007/10/03.