(5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

Base Information

Chemical Name:(5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid
CAS No.:159352-66-6
Molecular Formula:C₄₄H₇₈O₇Si₂
Molecular Weight:775.27
Hs Code.:

Synonyms:(5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

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Chemical Property of (5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

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Technology Process of (5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

There total 9 articles about (5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 108-55-4
glutaric anhydride,

: 159352-64-4
(5Z,7E)-(1S,3R)-1,3-bis(tert-butyldimethylsiloxy)-9,10-secocholesta-5,7,10(19)-trien-11α,25-diol

: 159352-66-6
(5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

Guidance literature:: With pyridine; for 120h; Ambient temperature;
DOI:10.1039/P19940001809

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 159352-66-6
(5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

2: 81 percent / pyridine / 3.5 h / Ambient temperature

3: 1.) Et₂O, irradiation, 2.) hexane, THF, room temperature, 14 days

4: 89 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

5: 92 percent / KOH / methanol / 0.83 h / 0 °C

6: 89 percent / pyridine / 120 h / Ambient temperature

With pyridine; 1H-imidazole; potassium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/P19940001809

Reference yield:

: 159352-63-3
(5Z,7E)-(1S,3R)-1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl acetate

: 159352-66-6
(5Z,7E)-(1S,3R)-4-<<1,3-bis(tert-butyldimethylsiloxy)-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-11α-yl>oxycarbonyl>butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / KOH / methanol / 0.83 h / 0 °C

2: 89 percent / pyridine / 120 h / Ambient temperature

With pyridine; potassium hydroxide; In methanol;
DOI:10.1039/P19940001809