4-Nitrophenyloxamic acid

Base Information

• Chemical Name: 4-Nitrophenyloxamic acid
• CAS No.: 103-94-6
• Molecular Formula: C8H6 N2 O5
• Molecular Weight: 210.146
• Hs Code.: 2924299090
• European Community (EC) Number: 203-160-1
• NSC Number: 57783
• UNII: D7SP5WLZ3P
• DSSTox Substance ID: DTXSID6059285
• Wikidata: Q81988728
• Mol file: 103-94-6.mol

Synonyms:4-nitrophenyloxamic acid;p-nitrophenyloxamic acid

Chemical Property of 4-Nitrophenyloxamic acid

Chemical Property:

• Melting Point: 204-205°C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 349.65°C (rough estimate)
• PKA: 1.55±0.25(Predicted)
• PSA: 112.22000
• Density: 1.629g/cm³
• LogP: 1.21410
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 210.02767130
• Heavy Atom Count: 15
• Complexity: 277

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Nitrophenyloxamic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)C(=O)O)[N+](=O)[O-]
• Uses: 4-Nitrophenyloxamic Acid (CAS# 103-94-6) has shown to have inhibitory effects on neuraminidase of Newcastle disease virus Kudu 113 strain.

Technology Process of 4-Nitrophenyloxamic acid

There total 8 articles about 4-Nitrophenyloxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxanilic acid (500-72-1) → mono-p-nitroanilide of oxalyl acid (103-94-6)

Guidance literature:

With nitric acid;

Reference yield:

3-oxo-3-phenyl-N-(4-nitrophenyl)propanamide (968-29-6) → mono-p-nitroanilide of oxalyl acid (103-94-6)

Guidance literature:

With ammonium cerium(IV) nitrate; In methanol; at 0 - 20 ℃;

DOI:10.1081/SCC-100000198

Reference yield:

N,N-bis-hydroxyoxalyl-4-nitro-aniline (861552-13-8) → mono-p-nitroanilide of oxalyl acid (103-94-6)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

oxanilic acid

N,N-bis-hydroxyoxalyl-4-nitro-aniline

oxalic acid

4-nitro-aniline

Downstream raw materials:

N-benzyl-N’-(4-nitrophenyl)urea

1-(furan-2-ylmethyl)-3-(4-nitrophenyl)urea

1-hexyl-3-(4-nitrophenyl)urea

4'-aminoxanilic acid

Refernces