3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

Base Information

Chemical Name:3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid
CAS No.:632625-04-8
Molecular Formula:C₂₅H₂₀ClNO₄
Molecular Weight:433.891
Hs Code.:

Synonyms:3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

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Chemical Property of 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

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Technology Process of 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

There total 4 articles about 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 632625-42-4
1-[5-chloro-2-(benzyloxy)phenyl]-pentane-1,4-dione

: 89-57-6
5-Aminosalicylic Acid

: 632625-04-8
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

Guidance literature:: toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.166667h; Microwave;

Reference yield:

: 38544-16-0
2-(benzyloxy)-5-chlorobenzaldehyde

: 632625-04-8
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

2: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield:

: 100-39-0
benzyl bromide

: 632625-04-8
3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 60 °C

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

3: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; DMF (N,N-dimethyl-formamide); ethanol;