4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide

Base Information

• Chemical Name: 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide
• CAS No.: 1215736-74-5
• Molecular Formula: BrH*C₁₅H₁₁ClN₂OS
• Molecular Weight: 383.696
• Mol file: 1215736-74-5.mol

Synonyms:4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide

Chemical Property of 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide

There total 3 articles about 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(4-hydroxyphenyl)thiourea (1520-27-0) + 4-chlorobenzoylmethyl bromide (536-38-9) → 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide (1215736-74-5)

Guidance literature:

In ethanol; at 80 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmc.2014.07.044

Reference yield:

para-chloroacetophenone (99-91-2) → 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide (1215736-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / chloroform / 2 h / 0 - 20 °C

2: ethanol / 0.5 h / 80 °C / Microwave irradiation

With bromine; In ethanol; chloroform; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.bmc.2014.07.044

Reference yield:

N1-Benzoyl-N2-<4-hydroxyphenyl>thiourea (5461-34-7) → 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol hydrobromide (1215736-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water / 1 h / 100 °C

2: ethanol / 0.5 h / 80 °C / Microwave irradiation

With sodium hydroxide; In tetrahydrofuran; ethanol; water; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.bmc.2014.07.044

upstream raw materials:

1-(4-hydroxyphenyl)thiourea

4-chlorobenzoylmethyl bromide

para-chloroacetophenone

N¹-Benzoyl-N²-<4-hydroxyphenyl>thiourea

Downstream raw materials:

4-[4-(4-chlorophenyl)thiazol-2-ylamino]phenol