2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-YL acetate

Base Information

Chemical Name:2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-YL acetate
CAS No.:872857-72-2
Molecular Formula:C₁₃H₁₃BrO₃
Molecular Weight:297.148
Hs Code.:
DSSTox Substance ID:DTXSID40700077
Wikidata:Q82631259
Mol file:872857-72-2.mol

Synonyms:872857-72-2;SCHEMBL903638;DTXSID40700077;QBPNUAACMXSMNN-UHFFFAOYSA-N;2-BROMO-6-METHOXY-3,4-DIHYDRONAPHTHALEN-1-YL ACETATE;ACETIC ACID 2-BROMO-6-METHOXY-3,4-DIHYDRO-NAPHTHALEN-1-YL ESTER

Suppliers and Price of 2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-YL acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-YL acetate

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:296.00481
Heavy Atom Count:17
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1=C(CCC2=C1C=CC(=C2)OC)Br

Technology Process of 2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-YL acetate

There total 2 articles about 2-Bromo-6-methoxy-3,4-dihydronaphthalen-1-YL acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20933-24-8
2-bromo-6-methoxy-1-tetralone

: 108-24-7
acetic anhydride

: 872857-72-2
acetic acid 2-bromo-6-methoxy-3,4-dihydro-naphthalen-1-yl ester

Guidance literature:: 2-bromo-6-methoxy-1-tetralone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

acetic anhydride; at -78 - 0 ℃; for 0.5h;

Reference yield:

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 872857-72-2
acetic acid 2-bromo-6-methoxy-3,4-dihydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine / diethyl ether / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: 0.5 h / 0 °C

With bromine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;

Reference yield: 71.0%

: 872857-72-2
acetic acid 2-bromo-6-methoxy-3,4-dihydro-naphthalen-1-yl ester

: 133730-34-4
2,4-dimethoxyphenylboronic acid

: 872857-74-4
2-(2,4-dimethoxyphenyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: acetic acid 2-bromo-6-methoxy-3,4-dihydro-naphthalen-1-yl ester; 2,4-dimethoxyphenylboronic acid; With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; Heating / reflux;

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;