5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

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Chemical Name:5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester
CAS No.:849599-83-3
Molecular Formula:C₄₈H₆₇N₉O₁₃
Molecular Weight:978.112
Hs Code.:

5-(2-{6-<i>tert</i>-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2<i>H</i>-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2<i>H</i>-pyrazole-3-carboxylic acid methyl ester

Synonyms:5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

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Chemical Property of 5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

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Technology Process of 5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

There total 7 articles about 5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 650609-89-5
2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid

: 940964-35-2
N^ε-tert-butyloxycarbonyl-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 849599-83-3
5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja045558b

Reference yield:

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 849599-83-3
5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-chloro-3-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂

2: aq. LiOH / methanol; tetrahydrofuran

3: 66 percent / 2-chloro-1-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂ / 20 °C

With lithium hydroxide; 1-chloro-3-methylpyridinium iodide; 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja045558b

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 849599-83-3
5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: HCTU; Cl-HOBt; 2,6-lutidine / CH₂Cl₂; dimethylformamide / 0.17 h / 0 °C

1.2: 52 percent / CH₂Cl₂; dimethylformamide

2.1: CF₃CO₂H / CH₂Cl₂

3.1: HCTU; Cl-HOBt; 2,6-lutidine / dimethylformamide; CH₂Cl₂ / 0.17 h / 0 °C

3.2: dimethylformamide; CH₂Cl₂

4.1: 80 percent / H₂ / Pd/C / methanol; tetrahydrofuran

5.1: 66 percent / 2-chloro-1-methylpyridinium iodide; diisopropylethylamine / CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 2-chloro-1-methyl-pyridinium iodide; hydrogen; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja045558b