diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Base Information

Chemical Name:diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate
CAS No.:126199-98-2
Molecular Formula:C₂₁H₂₄F₃NO₆S
Molecular Weight:475.486
Hs Code.:

Synonyms:diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

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Chemical Property of diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

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Technology Process of diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

There total 5 articles about diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 126199-97-1
diethyl 1,4-dihydro-2-methyl-6-<(methylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

: 126199-98-2
diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: With Oxone;
DOI:10.1016/S0040-4039(00)99253-0

Reference yield: 29.0%

: C₂₀H₂₀F₃LiNO₄^(1-)*Li⁽¹⁺⁾

: 124-63-0
methanesulfonyl chloride

: 126199-98-2
diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: In tetrahydrofuran; -78 degC upto room temperature;
DOI:10.1016/S0040-4039(00)99253-0

Reference yield:

: 23191-75-5
SKF 24260

: 126199-98-2
diethyl 1,4-dihydro-6-methyl-2-<(methylsulfonyl)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C

2: 83 percent / tetrahydrofuran / -78 degC upto room temperature

3: 71 percent / OXONE

With Oxone; n-butyllithium; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)99253-0