1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester
CAS No.:1380650-63-4
Molecular Formula:C₃₁H₃₀N₂O₅
Molecular Weight:510.59
Hs Code.:

Synonyms:1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

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Technology Process of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

There total 16 articles about 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 1257214-10-0
5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

: 1380650-63-4
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 1h;

Reference yield:

: 92855-14-6
1-(biphenyl-4-yl)cyclopropanecarbonitrile

: 1380650-63-4
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide; water / ethylene glycol / 3 h / 170 °C

2.1: sulfuric acid / 16 h / Reflux

3.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

4.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

5.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

5.2: 2 h / 50 °C

6.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere

8.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

With aluminum (III) chloride; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; hydrogen; bromine; triethylamine; potassium hydroxide; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethylene glycol; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 93022-07-2
1-(biphenyl-4-yl)cyclopropanecarboxylic acid

: 1380650-63-4
1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

4.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

4.2: 2 h / 50 °C

5.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere

7.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C

With aluminum (III) chloride; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; hydrogen; bromine; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;