Technology Process of 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester
There total 16 articles about 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 80 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium hydroxide; water / ethylene glycol / 3 h / 170 °C
2.1: sulfuric acid / 16 h / Reflux
3.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C
4.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C
5.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C
5.2: 2 h / 50 °C
6.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C
7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere
8.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C
With
aluminum (III) chloride; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; hydrogen; bromine; triethylamine; potassium hydroxide; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; ethylene glycol; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 16 h / Reflux
2.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C
3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C
4.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C
4.2: 2 h / 50 °C
5.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C
6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere
7.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C
With
aluminum (III) chloride; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; hydrogen; bromine; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
