5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

Base Information

Chemical Name:5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid
CAS No.:1257214-10-0
Molecular Formula:C₂₃H₂₁NO₅
Molecular Weight:391.423
Hs Code.:

Synonyms:5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

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Chemical Property of 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

Chemical Property:

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Technology Process of 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

There total 9 articles about 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380650-62-3
benzyl 5-(4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-yl)-3-methylisoxazole-4-carboxylate

: 1257214-10-0
5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 1.5h;

Reference yield:

: 93022-07-2
1-(biphenyl-4-yl)cyclopropanecarboxylic acid

: 1257214-10-0
5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

4.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

4.2: 2 h / 50 °C

5.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; bromine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1380650-55-4
ethyl 1-(4-phenylphenyl)cyclopropanecarboxylate

: 1257214-10-0
5-(4'-(1-(ethoxycarbonyl)cyclopropyl)-[1,1'-biphenyl]-4-yl)-3-methylisoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

2.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

3.2: 2 h / 50 °C

4.1: hydroxylamine hydrochloride / acetic acid / 1 h / 95 °C

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 20 h / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; hydroxylamine hydrochloride; water; hydrogen; bromine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;