Technology Process of dibutyl (2,3,4-trimethoxy-6-methylphenyl)boronate
There total 3 articles about dibutyl (2,3,4-trimethoxy-6-methylphenyl)boronate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-3,4,5-trimethoxy-1-methylbenzene;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
boric acid tributyl ester;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/hlca.201200564
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux
2.1: sodium acetate; acetic acid; bromine / tetrachloromethane / 2.5 h / 10 - 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
3.2: 4 h / 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); bromine; tert.-butyl lithium; sodium acetate; sodium carbonate; acetic acid;
In
tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; water;
1.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/hlca.201200564
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium acetate; acetic acid; bromine / tetrachloromethane / 2.5 h / 10 - 20 °C / Inert atmosphere
2.1: tert.-butyl lithium / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
With
bromine; tert.-butyl lithium; sodium acetate; acetic acid;
In
tetrahydrofuran; tetrachloromethane;
DOI:10.1002/hlca.201200564
