(S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:104897-95-2
Molecular Formula:C₂₈H₄₈BrNO₄S
Molecular Weight:574.663
Hs Code.:

Synonyms:(S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 32 articles about (S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 104897-89-4
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-hex-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104897-95-2
(R)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 104897-95-2
(S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With N-Bromosuccinimide; In 1,2-dimethoxyethane; at -78 ℃; for 0.5h; Yields of byproduct given. Title compound not separated from byproducts; d.e. 96percent;

Reference yield: 68.0%

: 104897-89-4
N,N-Dicyclohexyl-C-[(1S,2R,4R)-7,7-dimethyl-2-((E)-1-trimethylsilanyloxy-hex-1-enyloxy)-bicyclo[2.2.1]hept-1-yl]-methanesulfonamide

: 104897-95-2
(R)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 104897-95-2
(S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With N-Bromosuccinimide; In 1,2-dimethoxyethane; at -78 ℃; for 0.5h; Yields of byproduct given. Title compound not separated from byproducts; d.e. 96percent;

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 104897-95-2
(S)-2-Bromo-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: AgCN

2: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, - 78 deg C 2.) -78 deg C, 1 h.

3: 66 percent / N-Bromo-succinimide / 1,2-dimethoxy-ethane / 0.5 h / -78 °C / d.e. 96percent

4: 90 percent / Ca(BH₄)2 / tetrahydrofuran

5: AgCN

6: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, - 78 deg C 2.) -78 deg C, 1 h.

7: 68 percent / N-Bromo-succinimide / 1,2-dimethoxy-ethane / 0.5 h / -78 °C / d.e. 96percent

With N-Bromosuccinimide; n-butyllithium; calcium borohydride; silver cyanide; diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane;