6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Base Information

Chemical Name:6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid
CAS No.:1337469-48-3
Molecular Formula:C₂₃H₃₂N₂O₃
Molecular Weight:384.519
Hs Code.:

Synonyms:6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

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Chemical Property of 6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

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Technology Process of 6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

There total 5 articles about 6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1337469-47-2
6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

: 1337469-48-3
6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h;
DOI:10.1021/ml200197e

Reference yield:

: 1055233-46-9
methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1337469-48-3
6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: iodine; silver sulfate / methanol / 11 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 6 h / 20 °C

4: sodium hydroxide / methanol / 1 h / 60 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; iodine; potassium carbonate; silver sulfate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/ml200197e

Reference yield:

: 1337469-40-5
C₂₄H₃₀N₂O₃

: 1337469-48-3
6-[N-ethyl-N-(2-ethyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 1 h / 60 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In methanol;
DOI:10.1021/ml200197e