6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Base Information

Chemical Name:6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid
CAS No.:1337469-47-2
Molecular Formula:C₂₃H₂₈N₂O₃
Molecular Weight:380.487
Hs Code.:

Synonyms:6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

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Chemical Property of 6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Chemical Property:

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Technology Process of 6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

There total 3 articles about 6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1337469-40-5
C₂₄H₃₀N₂O₃

: 1337469-47-2
6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Guidance literature:: C₂₄H₃₀N₂O₃; With sodium hydroxide; In methanol; at 60 ℃; for 1h;

With hydrogenchloride; In methanol; water;
DOI:10.1021/ml200197e

Reference yield:

: 1337469-43-8
methyl 6-[N-ethyl-N-(2-iodo-5-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1337469-47-2
6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 6 h / 20 °C

3: sodium hydroxide / methanol / 1 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/ml200197e

Reference yield:

: 1055233-46-9
methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1337469-47-2
6-[N-ethyl-N-(2-ethynyl-5-isobutoxy-4-isopropylphenyl)amino]nicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; silver sulfate / methanol / 11 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 6 h / 20 °C

4: sodium hydroxide / methanol / 1 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; potassium carbonate; silver sulfate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/ml200197e