(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

Base Information

Chemical Name:(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate
CAS No.:1643461-41-9
Molecular Formula:C₃₃H₄₅N₃O₅
Molecular Weight:563.737
Hs Code.:

Synonyms:(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

Suppliers and Price of (S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

There total 8 articles about (S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1806-26-4
p-Octylphenol

: 1643461-40-8
(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(tosyloxy)propyl}-indazole-5-carboxylate

: 1643461-41-9
(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

Guidance literature:: p-Octylphenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(tosyloxy)propyl}-indazole-5-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 3h;
DOI:10.1039/c4ob00535j

Reference yield:

: 61700-61-6
1H-indazole-5-carboxylic acid

: 1643461-41-9
(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 3 h / 70 °C

3.1: hydrogenchloride / tetrahydrofuran / 3 h / 70 °C

4.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 3 h / 80 °C

With hydrogenchloride; dmap; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j

Reference yield:

: 1643461-26-0
allyl indazole-5-carboxylate

: 1643461-41-9
(S)-allyl 1-{2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)-propyl}indazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 3 h / 70 °C

2.1: hydrogenchloride / tetrahydrofuran / 3 h / 70 °C

3.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 3 h / 80 °C

With hydrogenchloride; dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j