4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

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Chemical Name:4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide
CAS No.:928038-28-2
Molecular Formula:C₂₃H₁₈F₂N₄O₄
Molecular Weight:452.417
Hs Code.:

Synonyms:4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

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Chemical Property of 4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

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Technology Process of 4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

There total 2 articles about 4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.2%

: 868733-71-5
4-(4-amino-2-fluorophenoxy)pyridin-2-carboxamide

: 928038-28-2
4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

Guidance literature:: ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h;

With thionyl chloride; In tetrahydrofuran; at 0 ℃; for 1h;

4-(4-amino-2-fluorophenoxy)pyridin-2-carboxamide; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 928038-28-2
4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 1 h / 80 °C

2.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1 h / 0 °C

2.3: 0 - 20 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;