N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:928038-29-3
Molecular Formula:C₂₂H₁₈F₂N₄O₃
Molecular Weight:424.407
Hs Code.:

Synonyms:N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Property of N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Technology Process of N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 3 articles about N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 928038-28-2
4-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridine-2-carboxamide

: 928038-29-3
N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 928038-29-3
N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C

1.2: 1 h / 80 °C

2.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1 h / 0 °C

2.3: 0 - 20 °C

3.1: pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene / N,N-dimethyl-formamide / 20 °C

With pyridine; potassium tert-butylate; water; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 868733-71-5
4-(4-amino-2-fluorophenoxy)pyridin-2-carboxamide

: 928038-29-3
N-{4-[(2-Aminopyridin-4-yl)oxy]-3-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1 h / 0 °C

1.3: 0 - 20 °C

2.1: pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene / N,N-dimethyl-formamide / 20 °C

With pyridine; water; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; N,N-dimethyl-formamide;