dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

Base Information

Chemical Name:dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate
CAS No.:1424371-19-6
Molecular Formula:C₂₇H₂₅ClN₂O₆
Molecular Weight:508.958
Hs Code.:

Synonyms:dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

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Chemical Property of dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

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Technology Process of dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

There total 4 articles about dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 70049-46-6
2,4-dichloro-6-methoxyquinoline

: 156304-06-2
dimethyl 4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

: 1424371-19-6
dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 48h; regioselective reaction;
DOI:10.1007/s11164-013-1085-4

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 1424371-19-6
dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / ethanol

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With ammonium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1007/s11164-013-1085-4

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1424371-19-6
dimethyl 4-(4-(2-chloro-6-methoxyquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1007/s11164-013-1085-4