1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline
• CAS No.: 879473-33-3
• Molecular Formula: C₁₇H₁₈N₂O₆S
• Molecular Weight: 378.406

Synonyms:1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline

Chemical Property of 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline

Chemical Property:

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Technology Process of 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline

There total 3 articles about 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-[2-(3,4-dimethoxyphenyl)ethyl]-4-nitrobenzenesulfonamide (321706-24-5) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline (879473-33-3)

Guidance literature:

With 12-tungstophosphoric acid hydrate; In acetonitrile; for 0.5h; Reflux; Green chemistry;

DOI:10.1016/j.cclet.2013.06.019

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline (879473-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane / 20 °C

2: formic acid / Reflux

With sodium carbonate; In formic acid; dichloromethane; 2: |Pictet-Spengler Synthesis;

DOI:10.1016/j.bmc.2015.04.036

Reference yield:

4-Nitrobenzenesulfonyl chloride (98-74-8) → 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline (879473-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane / 20 °C

2: formic acid / Reflux

With sodium carbonate; In formic acid; dichloromethane; 2: |Pictet-Spengler Synthesis;

DOI:10.1016/j.bmc.2015.04.036

upstream raw materials:

N-[2-(3,4-dimethoxyphenyl)ethyl]-4-nitrobenzenesulfonamide

formaldehyd

4-Nitrobenzenesulfonyl chloride

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

(1-(4-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol

6,7-dimethoxy-2-((4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

6,7-dimethoxy-2-((4-(4-((o-tolyloxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

6,7-dimethoxy-2-((4-(4-((p-tolyloxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline

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