methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Base Information

Chemical Name:methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid
CAS No.:182010-81-7
Molecular Formula:C₁₆H₂₁ClO₃
Molecular Weight:296.794
Hs Code.:

Synonyms:methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Suppliers and Price of methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

There total 7 articles about methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-5-chloro-3,4-dimethyl-phenyl]-4-methyl-hex-4-enoic acid methyl ester

: 182010-81-7
methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.166667h;
DOI:10.1021/jm9603633

Reference yield:

: 1570-76-9
2,3-dimethyl-4-chlorophenol

: 182010-81-7
methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / Ambient temperature

2: N,N-diethylaniline / 4 h / 200 °C

3: imidazole / dimethylformamide

4: 1.) pyridine, ozonized O₂, 2.) Me₃S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) CH₂Cl₂, MeOH, RT, overnight

5: tetrahydrofuran / -78 °C

6: pivalic acid / Heating

7: 1.0 M tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h

With pyridine; 1H-imidazole; ozone-containing oxygen; trimethylsulfonium; tetrabutyl ammonium fluoride; potassium carbonate; N,N-diethylaniline; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm9603633

Reference yield:

: 6-Allyl-4-chloro-2,3-dimethyl-phenol

: 182010-81-7
methyl (E)-6-(5-chloro-2-hydroxy-3,4-dimethylphenyl)-4-methyl-4-hexenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide

2: 1.) pyridine, ozonized O₂, 2.) Me₃S / 1.) CH₂Cl₂, MeOH, -78 deg C, 2.) CH₂Cl₂, MeOH, RT, overnight

3: tetrahydrofuran / -78 °C

4: pivalic acid / Heating

5: 1.0 M tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h

With pyridine; 1H-imidazole; ozone-containing oxygen; trimethylsulfonium; tetrabutyl ammonium fluoride; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm9603633