2-(3-{[3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl]isopropylamino}-1-phenylpropyl)-4-methylphenol

Base Information

Chemical Name:2-(3-{[3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl]isopropylamino}-1-phenylpropyl)-4-methylphenol
CAS No.:854306-71-1
Molecular Formula:C₄₂H₄₇NO₂
Molecular Weight:597.841
Hs Code.:
DSSTox Substance ID:DTXSID80468624

Synonyms:2-(3-{[3-(2-BENZYLOXY-5-METHYLPHENYL)-3-PHENYLPROPYL]ISOPROPYLAMINO}-1-PHENYLPROPYL)-4-METHYLPHENOL;854306-71-1;SCHEMBL4829373;DTXSID80468624;GXNHCHFPSIESSQ-UHFFFAOYSA-N

Suppliers and Price of 2-(3-{[3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl]isopropylamino}-1-phenylpropyl)-4-methylphenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-{[3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl]isopropylamino}-1-phenylpropyl)-4-methylphenol

Chemical Property:

XLogP3:10.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:14
Exact Mass:597.360679742
Heavy Atom Count:45
Complexity:797

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)O)C(CCN(CCC(C2=CC=CC=C2)C3=C(C=CC(=C3)C)OCC4=CC=CC=C4)C(C)C)C5=CC=CC=C5

Technology Process of 2-(3-{[3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl]isopropylamino}-1-phenylpropyl)-4-methylphenol

There total 7 articles about 2-(3-{[3-(2-Benzyloxy-5-methylphenyl)-3-phenylpropyl]isopropylamino}-1-phenylpropyl)-4-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

: 124937-99-1
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropyl-p-toluene sulphonate

: 480432-14-2
N-isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine

: 854306-71-1
N-(3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropyl)-N-isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropan-1-amine

Guidance literature:: In N,N-dimethyl-formamide; at 60 - 70 ℃; for 16h; under 2250.23 Torr; Autoclave; Inert atmosphere;
DOI:10.1021/op050024w

Reference yield:

: 106-44-5
p-cresol

: 854306-71-1
N-(3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropyl)-N-isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 120 - 125 °C

2: potassium carbonate / acetone / 3 h / Reflux

3: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 25 - 35 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 35 °C

5: N,N-dimethyl-formamide / 16 h / 60 - 70 °C / 2250.23 Torr / Autoclave; Inert atmosphere

With sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/op050024w

Reference yield:

: 854306-68-6
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol

: 854306-71-1
N-(3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropyl)-N-isopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 35 °C

2: N,N-dimethyl-formamide / 16 h / 60 - 70 °C / 2250.23 Torr / Autoclave; Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/op050024w