(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

Base Information

Chemical Name:(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone
CAS No.:1451993-06-8
Molecular Formula:C₁₈H₁₇N₇OS
Molecular Weight:379.445
Hs Code.:

Synonyms:(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

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Chemical Property of (5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

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Technology Process of (5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

There total 5 articles about (5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452226-14-0
5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

: 1451998-29-0
3-azido-3-phenylazetidine trifluoroacetate

: 1451993-06-8
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

Guidance literature:: 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

3-azido-3-phenylazetidine trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1451993-06-8
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.2 h / 0 °C / Inert atmosphere

1.2: 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 16 h / 65 °C

4.1: dichloromethane / 1 h / 20 °C

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 0.5 h / 20 °C

With sodium azide; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1451998-27-8
tert-butyl 3-((methylsulfonyl)oxy)-3-phenylazetidine-1-carboxylate

: 1451993-06-8
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-azido-3-phenylazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 16 h / 65 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 0.5 h / 20 °C

With sodium azide; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;