(S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

Base Information

Chemical Name:(S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide
CAS No.:1396507-21-3
Molecular Formula:C₂₄H₃₉FN₂O₂Si
Molecular Weight:434.67
Hs Code.:

Synonyms:(S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

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Technology Process of (S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

There total 7 articles about (S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1396506-38-9
5-(di-tert-butylfluorosilyl)-2-methoxybenzoic acid

: 66411-51-6
1-[(S)-1-allylpyrrolidin-2-yl]methanamine

: 1396507-21-3
(S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

Guidance literature:: With pyridine; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; for 22h;
DOI:10.3390/molecules16097458

Reference yield:

: 1396506-79-8
5-(di-tert-butylfluorosilyl)-2-methoxybenzaldehyde

: 1396507-21-3
(S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium permanganate / dichloromethane; tert-butyl alcohol / 3 h / 20 °C / pH 3 / aq. phosphate buffer

2: pyridine; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / chloroform / 22 h / 0 - 20 °C

With pyridine; potassium permanganate; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; tert-butyl alcohol;
DOI:10.3390/molecules16097458

Reference yield:

: 1396506-65-2
di-tert-butyl(3-((tert-butyldimethylsilyloxy)methyl)-4-methoxyphenyl)fluorosilane

: 1396507-21-3
(S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(di-tert-butylfluorosilyl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol; water / 19 h / 20 °C

2: pyridinium chlorochromate / dichloromethane / 20 °C / Cooling with ice

3: potassium permanganate / dichloromethane; tert-butyl alcohol / 3 h / 20 °C / pH 3 / aq. phosphate buffer

4: pyridine; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / chloroform / 22 h / 0 - 20 °C

With pyridine; hydrogenchloride; potassium permanganate; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; pyridinium chlorochromate; In methanol; dichloromethane; chloroform; water; tert-butyl alcohol;
DOI:10.3390/molecules16097458