4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

Base Information

Chemical Name:4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate
CAS No.:1268822-09-8
Molecular Formula:C₁₇H₁₄F₂N₆O₃S
Molecular Weight:420.399
Hs Code.:

Synonyms:4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

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Chemical Property of 4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

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Technology Process of 4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

There total 11 articles about 4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1268822-08-7
4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

: 1268822-09-8
4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300015

Reference yield:

: 886498-98-2
2-(2,6-difluoro-4-methoxyphenyl)acetic acid

: 1268822-09-8
4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / water / Reflux

2.1: boron tribromide / dichloromethane / 3.6 h / -78 - 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

5.1: triphenylphosphine; carbon tetrabromide / 3 h / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

6.2: 48 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

8.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; carbon tetrabromide; sulphamoyl chloride; tetrabutyl ammonium fluoride; boron tribromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015

Reference yield:

: 1268822-66-7
methyl 2-[2,6-difluoro-4-(triisopropylsilyloxy)phenyl]acetate

: 1268822-09-8
4-{2-[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]ethyl}-2,6-difluorophenyl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

2.1: triphenylphosphine; carbon tetrabromide / 3 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

3.2: 48 h

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sulphamoyl chloride; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015