4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

Base Information

Chemical Name:4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile
CAS No.:1268822-08-7
Molecular Formula:C₁₇H₁₃F₂N₅O
Molecular Weight:341.32
Hs Code.:

Synonyms:4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

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Chemical Property of 4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

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Technology Process of 4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

There total 10 articles about 4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₃F₂N₅OSi

: 1268822-08-7
4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1002/cmdc.201300015

Reference yield:

: 886498-98-2
2-(2,6-difluoro-4-methoxyphenyl)acetic acid

: 1268822-08-7
4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / water / Reflux

2.1: boron tribromide / dichloromethane / 3.6 h / -78 - 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

5.1: triphenylphosphine; carbon tetrabromide / 3 h / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

6.2: 48 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; carbon tetrabromide; tetrabutyl ammonium fluoride; boron tribromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015

Reference yield:

: 1268822-64-5
methyl 2-(2,6-difluoro-4-methoxyphenyl)acetate

: 1268822-08-7
4-[(2,6-difluoro-4-hydroxyphenethyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 3.6 h / -78 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

4.1: triphenylphosphine; carbon tetrabromide / 3 h / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

5.2: 48 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; carbon tetrabromide; tetrabutyl ammonium fluoride; boron tribromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015