tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Base Information

Chemical Name:tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate
CAS No.:102208-46-8
Molecular Formula:C₂₇H₃₆N₂O₅S₂
Molecular Weight:532.725
Hs Code.:

Synonyms:tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Suppliers and Price of tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

There total 10 articles about tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 88767-98-0,138333-09-2
ethyl (R)-4-phenyl-2-<<(trifluoromethyl)sulfonyl>oxy>butyrate

: 102090-03-9
tert-butyl <(3S,6R)-6-amino-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

: 102208-46-8
tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Guidance literature:: With triethylamine; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00394a009

Reference yield:

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 102208-46-8
tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 82 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; triethylamine; In dichloromethane;
DOI:10.1021/jm00394a009

Reference yield:

: 1914-59-6
(E)-2-oxo-4-phenyl-3-butenoic acid

: 102208-46-8
tert-butyl α-<(3S,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-3-(2-thienyl)perhydro-1,4-thiazepin-4-yl>acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / p-toluenesulfonic acid*H₂O / benzene / 5 h / Heating

2: 29 percent / H₂ / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr

3: 86 percent / KOH / ethanol / 16 h / Ambient temperature

4: 98 percent / conc. H₂SO₄ / 16 h / Ambient temperature

5: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

6: 82 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; potassium hydroxide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jm00394a009