1914-59-6Relevant academic research and scientific papers
Catalytic Three-Component Synthesis of Functionalized Naphtho[2,1-b]oxecines via a Double Bond Cleavage-Rearrangement Cascade
Ji, Cheng-Long,Hao, Wen-Juan,Zhang, Jie,Geng, Fang-Zhou,Xu, Ting,Tu, Shu-Jiang,Jiang, Bo
, p. 6494 - 6498 (2019)
A new double annulation cascade involving a [2 + 2] cycloaddition-retroelectrocyclization (CA-RE) process was first reported, leading to the generation of unprecedented dibenzoannulated naphtho[2,1-b]oxecines with good to excellent yields and high stereos
Characterization of the aldol condensation activity of the trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (tHBP-HA) cloned from Pseudomonas fluorescens N3
Ferrara, Silvia,Mapelli, Erika,Sello, Guido,Di Gennaro, Patrizia
, p. 622 - 629 (2011)
The gene encoding trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (tHBP-HA) was isolated from Pseudomonas fluorescens N3, an environmental strain able to degrade naphthalene. This enzyme is an aldolase of class I that reversibly catalyzes the transf
Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold
Mydy, Lisa S.,Hoppe, Robert W.,Ochsenwald, Jenna M.,Berndt, Robert T.,Severin, Geoffrey B.,Schwabacher, Alan W.,Silvaggi, Nicholas R.
, p. 3978 - 3988 (2015)
The acetoacetate decarboxylase-like superfamily (ADCSF) is a group of ～4000 enzymes that, until recently, was thought to be homogeneous in terms of the reaction catalyzed. Bioinformatic analysis shows that the ADCSF consists of up to seven families that d
Iridium/f-Amphox-Catalyzed Asymmetric Hydrogenation of Styrylglyoxylamides
Wang, Simin,Yu, Yuena,Wen, Jialin,Zhang, Xumu
supporting information, p. 2203 - 2207 (2018/09/29)
We report an iridium-catalyzed asymmetric hydrogenation reaction for the preparation of chiral homophenylalanine derivatives. Catalyzed by an iridium/f-amphox complex, the asymmetric hydrogenation of styrylglyoxylamides was conducted smoothly with turnover numbers of up to 10,000 and up to 98% ee. This method was successfully applied in a synthesis of a fragment of benazepril, a drug used for the treatment of high blood pressure.
N-Heterocyclic Carbene-Catalyzed Umpolung of Alkynyl 1,2-Diketones
Kong, Xiangwen,Zhang, Guoxiang,Yang, Shuang,Liu, Xiaozhi,Fang, Xinqiang
supporting information, p. 2729 - 2734 (2017/08/23)
The umpolung of alkynyl 1,2-diketones via N-heterocyclic carbene (NHC) catalysis was achieved for the first time, allowing the rapid access to a large variety of synthetically and pharmaceutically important α-pyrones under very mild conditions. A completely new NHC-catalyzed umpolung pattern involving an O-acylated allenolate as the key intermediate was proposed. Moreover, an unprecedented reaction pathway, featured by a series of group migrations and new bond formation, was postulated to demonstrate the formation of the products. (Figure presented.).
SUBSTITUTED DIHYDROPYRAZOLES AS SPHINGOSINE RECEPTOR MODULATORS
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Paragraph 0131-0133, (2014/08/19)
The present invention relates to substituted dihydropyrazoles, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
SUBSTITUTED PYRAZOLE AZETIDINES AS SPHINGOSINE RECEPTOR MODULATORS
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Paragraph 0126-0128, (2014/08/19)
The present invention relates to substituted pyrazole azetidines, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
SUBSTITUTED PYRAZOLES AS SPHINGOSINE RECEPTOR MODULATORS
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Paragraph 0139; 0140; 0141, (2014/09/03)
The present invention relates to substituted pyrazoles, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Highly enantioselective intermolecular stetter reactions of β-aryl acceptors: α-ketoester moiety as handle for activation and synthetic manipulations
Sanchez-Larios, Eduardo,Thai, Karen,Bilodeau, Francois,Gravel, Michel
supporting information; experimental part, p. 4942 - 4945 (2011/11/29)
The use of β,γ-unsaturated-α-ketoesters in the intermolecular Stetter reaction furnishes 1,2,5-tricarbonyl compounds in high yield and excellent enantioselectivity. The α,δ-diketoesters generated using this methodology serve as useful synthetic building b
Synthesis of some substituted furan-2(5H)-ones and derived quinoxalinones as potential anti-microbial and anti-cancer agents
El-Tombary, Alaa A.,Abdel-Ghany, Yasser S.,Belal, Ahmad S.F.,Shams El-Dine, Shams A.,Soliman, Farid S.G.
experimental part, p. 865 - 876 (2012/05/04)
In search for novel anti-cancer and antimicrobial agents with promising pharmacotoxicological profile, the synthesis of some substituted 4-halofuran- 2(5H)-ones (8a-l, 9, 11) and derived halogenated quinoxalin-2(1H)-ones (12a-d) is described. Some of the halogenated furanones were readily oxidized to the corresponding 2-bromo-2-propenoic acids (13a-c) with hydrogen peroxide in alkaline medium. Twenty-two compounds were preliminary tested for their in vitro activity against three bacteria and one fungus and revealed encouraging activity. On the other hand, three compounds were screened as anti-cancer agents using cell line panel protocol and 22 compounds were subjected to cycline-dependent kinases (CDKs) inhibition screening program but were inactive. Springer Science+Business Media, LLC 2010.
