1914-59-6Relevant articles and documents
Catalytic Three-Component Synthesis of Functionalized Naphtho[2,1-b]oxecines via a Double Bond Cleavage-Rearrangement Cascade
Ji, Cheng-Long,Hao, Wen-Juan,Zhang, Jie,Geng, Fang-Zhou,Xu, Ting,Tu, Shu-Jiang,Jiang, Bo
, p. 6494 - 6498 (2019)
A new double annulation cascade involving a [2 + 2] cycloaddition-retroelectrocyclization (CA-RE) process was first reported, leading to the generation of unprecedented dibenzoannulated naphtho[2,1-b]oxecines with good to excellent yields and high stereos
Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold
Mydy, Lisa S.,Hoppe, Robert W.,Ochsenwald, Jenna M.,Berndt, Robert T.,Severin, Geoffrey B.,Schwabacher, Alan W.,Silvaggi, Nicholas R.
, p. 3978 - 3988 (2015)
The acetoacetate decarboxylase-like superfamily (ADCSF) is a group of ~4000 enzymes that, until recently, was thought to be homogeneous in terms of the reaction catalyzed. Bioinformatic analysis shows that the ADCSF consists of up to seven families that d
Iridium/f-Amphox-Catalyzed Asymmetric Hydrogenation of Styrylglyoxylamides
Wang, Simin,Yu, Yuena,Wen, Jialin,Zhang, Xumu
supporting information, p. 2203 - 2207 (2018/09/29)
We report an iridium-catalyzed asymmetric hydrogenation reaction for the preparation of chiral homophenylalanine derivatives. Catalyzed by an iridium/f-amphox complex, the asymmetric hydrogenation of styrylglyoxylamides was conducted smoothly with turnover numbers of up to 10,000 and up to 98% ee. This method was successfully applied in a synthesis of a fragment of benazepril, a drug used for the treatment of high blood pressure.
SUBSTITUTED DIHYDROPYRAZOLES AS SPHINGOSINE RECEPTOR MODULATORS
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Paragraph 0131-0133, (2014/08/19)
The present invention relates to substituted dihydropyrazoles, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.