tert-butyl 2-chloro-6-(diethylamino)isonicotinate

Base Information

Chemical Name:tert-butyl 2-chloro-6-(diethylamino)isonicotinate
CAS No.:1365337-42-3
Molecular Formula:C₁₄H₂₁ClN₂O₂
Molecular Weight:284.786
Hs Code.:

Synonyms:tert-butyl 2-chloro-6-(diethylamino)isonicotinate

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Chemical Property of tert-butyl 2-chloro-6-(diethylamino)isonicotinate

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Technology Process of tert-butyl 2-chloro-6-(diethylamino)isonicotinate

There total 1 articles about tert-butyl 2-chloro-6-(diethylamino)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1365337-42-3
tert-butyl 2-chloro-6-(diethylamino)isonicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / Reflux

2: 100 °C / Autoclave

In toluene;
DOI:10.1021/op200326s

Reference yield:

: 1365337-42-3
tert-butyl 2-chloro-6-(diethylamino)isonicotinate

: 1062671-19-5
4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,3,4-oxadiazol-2-yl)-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; tetrahydrofuran / 16 h / 75 °C / Inert atmosphere

2: hydrogenchloride / water / 24 h / 80 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 1.17 h / 20 °C / Inert atmosphere

4: Burgess Reagent / tetrahydrofuran / 0.08 h / 110 °C / Microwave irradiation; Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 5 h / 20 °C / 750.08 Torr / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Burgess Reagent; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4014696

Reference yield:

: 1365337-42-3
tert-butyl 2-chloro-6-(diethylamino)isonicotinate

: 1062671-30-0
C₂₄H₃₃N₅O₃

Guidance literature:: Multi-step reaction with 7 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; tetrahydrofuran / 16 h / 75 °C / Inert atmosphere

2: hydrogenchloride / water / 24 h / 80 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 1.17 h / 20 °C / Inert atmosphere

4: Burgess Reagent / tetrahydrofuran / 0.08 h / 110 °C / Microwave irradiation; Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 5 h / 20 °C / 750.08 Torr / Inert atmosphere

6: sodium hydroxide / water; isopropyl alcohol / 20 °C

7: ammonia / methanol / 60 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Burgess Reagent; palladium 10% on activated carbon; ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm4014696