1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile

Base Information

• Chemical Name: 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile
• CAS No.: 1332392-07-0
• Molecular Formula: C₁₁H₁₁FN₂O
• Molecular Weight: 206.22
• Mol file: 1332392-07-0.mol

Synonyms:1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile

Chemical Property of 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile

There total 1 articles about 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium cyanide (773837-37-9) + cyclobutanone (1191-95-3) + 4-amino-2-fluorophenol (399-96-2) → 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile (1332392-07-0)

Guidance literature:

In acetic acid; at 20 ℃; for 6h;

Reference yield:

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile (573762-62-6) + thiophosgene (463-71-8) + 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile (1332392-07-0) → 5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile (1332388-81-4)

Guidance literature:

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile; In N,N-dimethyl acetamide; at 60 ℃; for 18h;

With hydrogenchloride; water; In methanol; N,N-dimethyl acetamide; for 2h; Reflux;

Reference yield:

1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile (1332392-07-0) → 5-(5-(3-fluoro-4-methoxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile (1332390-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl acetamide / 18 h / 60 °C

1.2: 2 h / Reflux

2.1: potassium carbonate / acetone / 4 h / 20 °C

With potassium carbonate; In N,N-dimethyl acetamide; acetone;

upstream raw materials:

sodium cyanide

cyclobutanone

4-amino-2-fluorophenol

Downstream raw materials:

5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

5-(5-(3-fluoro-4-(2-(1-methyl-1H-pyrazol-5-yl)ethoxy)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

5-[8-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-6-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile

5-(5-(4-(benzyloxy)-3-fluorophenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile