5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Base Information

Chemical Name:5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile
CAS No.:1332388-81-4
Molecular Formula:C₁₉H₁₂F₄N₄O₂S
Molecular Weight:436.389
Hs Code.:

Synonyms:5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

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Chemical Property of 5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

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Technology Process of 5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

There total 6 articles about 5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

: 463-71-8
thiophosgene

: 1332392-07-0
1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile

: 1332388-81-4
5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Guidance literature:: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; 1-((3-fluoro-4-hydroxyphenyl)amino)cyclobutanecarbonitrile; In N,N-dimethyl acetamide; at 60 ℃; for 18h;

With hydrogenchloride; water; In methanol; N,N-dimethyl acetamide; for 2h; Reflux;

Reference yield:

: 887707-23-5
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

: 1332388-81-4
5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 110 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / Reflux; Inert atmosphere

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 170 °C / Reflux; Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: N,N-dimethyl acetamide / 18 h / 60 °C

5.2: 2 h / Reflux

With trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 887707-25-7
2-chloro-5-iodo-3-(trifluoromethyl)pyridine

: 1332388-81-4
5-(5-(3-fluoro-4-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / Reflux; Inert atmosphere

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 170 °C / Reflux; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: N,N-dimethyl acetamide / 18 h / 60 °C

4.2: 2 h / Reflux

With trifluoroacetic acid; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;