5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole
CAS No.:1228372-45-9
Molecular Formula:C₁₆H₇Cl₂F₃N₄O
Molecular Weight:399.159
Hs Code.:

Synonyms:5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole

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Technology Process of 5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole

There total 2 articles about 5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 873-32-5
2-Chlorobenzonitrile

: 1113-59-3
bromopyruvic acid

: 79456-26-1
2-amino-3-chloro-5-(trifluoromethyl)pyridine

: 1228372-45-9
5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-3-(2-chlorophenyl)-1,2,4-oxadiazole

Guidance literature:: bromopyruvic acid; 2-amino-3-chloro-5-(trifluoromethyl)pyridine; In N,N-dimethyl acetamide; at 100 ℃; Flow reactor;

2-Chlorobenzonitrile; With hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 150 ℃; for 0.25h; under 3000.3 Torr; Flow reactor;
DOI:10.3762/bjoc.13.26