2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate

Base Information

• Chemical Name: 2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate
• CAS No.: 946082-11-7
• Molecular Formula: C₂₄H₃₇ClN₂O₁₁
• Molecular Weight: 565.018
• Mol file: 946082-11-7.mol

Synonyms:2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate

Chemical Property of 2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate

There total 2 articles about 2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride (1035373-85-3) + C20H20N2O12 (669012-99-1) → 2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate (946082-11-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201209662

Reference yield:

1-chloro-6-iodohexane (34683-73-3) → 2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate (946082-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1002/anie.201209662

Reference yield: 50.0%

2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate (946082-11-7) + N-(trans-4-((6-aminohexyl)carbamoyl)cyclohexyl)-4-(2-(ethyl(m-tolyl)amino)-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-5-carboxamide → 1-(trans-4-(4-(2-(ethyl(m-tolyl)amino)-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-5-carboxamido)cyclohexyl)-1,10-dioxo-11,14,17-trioxa-2,9-diazanonadecan-19-yl (2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

upstream raw materials:

1-chloro-6-iodohexane

2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride

C₂₀H₂₀N₂O₁₂

Downstream raw materials:

C₄₁H₆₀ClN₇O₁₀

C₃₃H₅₅ClN₄O₁₁

C₄₃H₆₆ClN₁₁O₁₂