34683-73-3

Basic information

• Product Name: 1-CHLORO-6-IODOHEXANE
• Synonyms: 1-CHLORO-6-IODOHEXANE 95%;1-Chloro-6-iodohexane (stabilized with Copper chip);HEXAMETHYLENE CHLOROIODIDE;1-CHLORO-6-IODOHEXANE;Hexane, 1-chloro-6-iodo-;1-Chloro-6-iodohexane,97%
• CAS NO: 34683-73-3
• Molecular Formula: C6H12ClI
• Molecular Weight: 246.52
• EINECS: 252-144-0
• Product Categories: Alkyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 34683-73-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 110 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.623 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: n20/D 1.5230(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: Acetonitrile (Slightly), Chloroform (Sparingly), Methanol (Sparingly)
• Water Solubility: Not miscible in water.
• Sensitive: Light Sensitive
• BRN: 1732408
• CAS DataBase Reference: 1-CHLORO-6-IODOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-6-IODOHEXANE(34683-73-3)
• EPA Substance Registry System: 1-CHLORO-6-IODOHEXANE(34683-73-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 34683-73-3(Hazardous Substances Data)

Usage

Uses

1-Chloro-6-iodohexane is used as :Pharmaceutical intermediates.

General Description

1-Chloro-6-iodohexane is an α,ω-dihaloalkane. 1,12-dichlorododecane is formed as a major product from the reduction of 1-chloro-6-iodohexane with nickel(I) salen. It affords 8-chloro-1-octyne on coupling with sodium acetylide.

InChI:InChI=1/C6H5ClIN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

Upstream product

• 2163-00-0 1,6-dichlorohexane 
• 401566-80-1 tert-butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate 
• 401564-36-1 (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 
• 84348-37-8 N-tert-butoxycarbonyl-4-oxo-L-proline 
• 87691-27-8 N-tert-butoxycarbonyl-L-cis-4-hydroxyproline 
• 618-27-9 hydroxy L-proline 
• 591-50-4 iodobenzene 
• 41327-15-5 5-bromo-3-methyl-1-phenyl-1H-pyrazole 
• 100-63-0 phenylhydrazine 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 401566-79-8 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine 
• 906093-30-9 1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate 
• 88050-17-3 N-Fmoc-trans-4-Hydroxy-L-Proline 

Downstream Products

• 24088-97-9 8-chloro-oct-1-yne 
• 56554-74-6 1-chloro-7-heptadecyne 
• 426260-98-2 13-chloro-1-(tert-butyldiphenylsilyloxy)tridec-6-yne 
• 20701-68-2 (9Z)-octadec-9-enedioic acid 
• 18287-34-8 meso-9,10-dihydroxy-octadecanedioic acid 
• 7432-41-9 8(Z)-heptadecenoic acid 
• 1617543-82-4 C₁₈H₂₃ClINO₆ 
• 1617543-83-5 C₁₈H₂₃I₂NO₆ 
• 1617543-84-6 C₂₃H₃₀INO₁₀ 
• 1617543-85-7 C₃₄H₅₀INO₁₀Si 
• 1617543-62-0 C₃₄H₅₂INO₈Si 
• 1209005-66-2 C₁₈H₂₈Cl₂O₂ 

Relevant articles and documents

Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an Aromatization-Dearomatization Strategy

We report, for the first time, manganese-mediated direct functionalization of the Hantzsch esters with readily accessible alkyl iodides through an aromatization-dearomatization strategy. Applying this protocol, a library of valuable 4-alkyl-1,4-dihydropyridines were facilely afforded in good yields. This simple and practical reaction proceeds under visible-light irradiation at room temperature and displays high functional-group compatibility. Additionally, the method is applicable for gram-scale synthesis and late-stage functionalization of complex molecules.

Preparation method of 1-chloro-6-iodohexane

The invention discloses a preparation method of 1-chloro-6-iodohexane. The preparation method comprises the steps of with 6-chloro-1-hexanol and p-toluene sulfochloride as the materials and benzene ortoluene as a solvent, reacting at (-5)-(5) DEG C for 2-5 hours under the effects of a phase transfer catalyst and an acid-binding agent so as to prepare 4-methylbenzenesulfonic acid-6-chlorohexyl ester, and carrying out reflux reaction on 4-methylbenzenesulfonic acid-6-chlorohexyl ester and sodium iodide for 0.5-3 hours, so as to prepare 1-chloro-6-iodohexane. The preparation method has the characteristics of easiness in operation, simplicity and convenience in after-treatment and relatively high yield.

Method for preparing hydrobromic acid teneligliptin

The invention provides a method for preparing hydrobromic acid teneligliptin. The method includes steps of preparing L-hydroxyproline; mixing the L-hydroxyproline and sodium bicarbonate with each other to obtain mixtures, dissolving the mixtures in water, adding acetone into the water, dropping di-tert-butyl dicarbonate into the water, carrying out room-temperature reaction overnight and then treating reaction products to obtain t-butyloxycarboryl-N-hydroxyproline; preparing t-butyloxycarboryl-N-4-oxo-proline from the t-butyloxycarboryl-N-hydroxyproline; preparing (2S)-4-oxo-2-(3-thiazolidine carbonyl)-1-pyrrolidine carboxylic acid tert-butyl ester from the t-butyloxycarboryl-N-4-oxo-proline; preparing compounds III from compounds IV; preparing compounds II from the compounds III; preparing compounds 1-(3-methyl-1-phenyl-1H-pyrazole-5-base) piperazine from the compounds II; preparing intermediates I; preparing the hydrobromic acid teneligliptin from the intermediates I. The method has the advantages that the method is low in cost, and the cost of the method is only two-thirds of the cost of an existing method in the prior art; the yield of the hydrobromic acid teneligliptin is higher than 95%, and the purity of the hydrobromic acid teneligliptin is higher than 98%.