2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride

Base Information

• Chemical Name: 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride
• CAS No.: 1035373-85-3
• Molecular Formula: C₁₀H₂₂ClNO₂*ClH
• Molecular Weight: 260.204
• Mol file: 1035373-85-3.mol

Synonyms:2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride

Chemical Property of 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride

There total 4 articles about 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl N-[2-{2-(6-chlorohexyloxy)ethoxy}ethyl]carbamate (920264-35-3) → 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride (1035373-85-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 45.0%

1-chloro-6-iodohexane (34683-73-3) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride (1035373-85-3)

Guidance literature:

2-(2-Aminoethoxy)ethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.75h; Inert atmosphere;

1-chloro-6-iodohexane; In N,N-dimethyl-formamide; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201209662

Reference yield:

6-chloro-1-hexanol (2009-83-8) → 2-[2-(6-chloro-hexyloxy)ethoxy]ethylammonium hydrochloride (1035373-85-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; dmap; potassium tert-butylate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

1-chloro-6-iodohexane

2-(2-Aminoethoxy)ethanol

tert-butyl N-[2-{2-(6-chlorohexyloxy)ethoxy}ethyl]carbamate

6-chloro-1-hexanol

Downstream raw materials:

2-(2-(2-(((4-nitrophenoxy)carbonyl)oxy)ethoxy)ethoxy)ethyl (2-(2-((6-chlorohexyl)oxy)ethoxy))ethylcarbamate

C₃₀H₄₂ClN₉O₆

C₄₅H₅₅ClN₃O₆⁽¹⁺⁾

C₄₃H₅₄ClN₃O₈S₂