2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

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Chemical Name:2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one
CAS No.:1643537-03-4
Molecular Formula:C₂₂H₂₃N₃O₄
Molecular Weight:393.442
Hs Code.:

Synonyms:2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

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Chemical Property of 2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

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Technology Process of 2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

There total 4 articles about 2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1643537-01-2
(Z)-5-methyl-4-[(3R,4R)-3-methyl-5-nitro-4-phenylpentan-2-ylidene]-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

: 1643537-03-4
2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In methanol; at 20 ℃; for 1h;
DOI:10.1002/adsc.201300964

Reference yield:

: 100-63-0
phenylhydrazine

: 1643537-03-4
2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 8 h / Reflux

2: pyridine; titanium(IV) isopropylate / 20 °C

3: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((2S,4S,8R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)thiourea / toluene / 24 h / -30 °C

4: dihydrogen peroxide; sodium hydroxide / methanol / 1 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((2S,4S,8R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)thiourea; pyridine; titanium(IV) isopropylate; dihydrogen peroxide; acetic acid; sodium hydroxide; In methanol; toluene; 3: |Michael Addition;
DOI:10.1002/adsc.201300964

Reference yield:

: 111064-16-5
(Z)-4-(butan-2-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

: 1643537-03-4
2,7-dimethyl-2-[(2R,3R)-4-nitro-3-phenylbutan-2-yl]-5-phenyl-1-oxa-5,6-diazaspiro[2.4]hept-6-en-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((2S,4S,8R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)thiourea / toluene / 24 h / -30 °C

2: dihydrogen peroxide; sodium hydroxide / methanol / 1 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-((2S,4S,8R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)thiourea; dihydrogen peroxide; sodium hydroxide; In methanol; toluene; 1: |Michael Addition;
DOI:10.1002/adsc.201300964