6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

Base Information

Chemical Name:6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene
CAS No.:114506-26-2
Molecular Formula:C₂₈H₂₈O₈S
Molecular Weight:524.592
Hs Code.:

Synonyms:6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

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Chemical Property of 6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

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Technology Process of 6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

There total 7 articles about 6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 114506-25-1
C₃₀H₃₂O₉S

: 114506-26-2
6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 5h;
DOI:10.1021/jo00248a014

Reference yield:

: 52506-21-5
8-oxo-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid methyl ester

: 114506-26-2
6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 25 deg C, 30 min, 2.) 0 deg C, 6 h

2: 95 percent / aq. 10percent HCl / tetrahydrofuran / 5 h

With hydrogenchloride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00248a014

Reference yield:

: 35993-25-0
1,4-dimethoxy-3-(hyroxymethyl)-2-methylnaphthalene

: 114506-26-2
6,11-dimethoxy-4a-hydroxy-12a-(methoxycarbonyl)-2-oxo-5-(phenylsulfonyl)-1,2,3,4,4a,5,12,12a-octahydronaphthacene

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, Me₂S / tetrahydrofuran / 3 h

2: dimethylformamide / 2 h / Ambient temperature

3: 93 percent / NBS, benzoyl peroxide / CCl₄ / 0.5 h / Heating; Irradiation

4: 1.) NaH / 1.) THF, 25 deg C, 30 min, 2.) 0 deg C, 6 h

5: 95 percent / aq. 10percent HCl / tetrahydrofuran / 5 h

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; dimethylsulfide; sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00248a014