52506-21-5

Basic information

• Product Name: methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
• Synonyms: methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
• CAS NO: 52506-21-5
• Molecular Formula: C₁₀H₁₄O₅
• Molecular Weight: 214.21516
• Mol File: 52506-21-5.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate(52506-21-5)
• EPA Substance Registry System: methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate(52506-21-5)

Safety Data

• Hazardous Substances Data: 52506-21-5(Hazardous Substances Data)

Usage

General Description

Methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate is a complex organic compound with a spirocyclic structure. It is classified as an ester, containing both a carbonyl group and a spiro ring system. This chemical is often used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds. Its unique structure and reactivity make it a valuable intermediate for the production of drugs and other pharmaceutical products. Additionally, it has potential applications in the field of organic synthesis and chemical research due to its interesting molecular architecture and properties.

Upstream product

• 86488-09-7 4-ethylenedioxy-1,7-heptanedionic acid, dimethyl ester 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 874360-02-8 methyl 8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate 
• 874360-03-9 methyl 8-(2,4,5-trifluorophenyl)-1,4-dioxaspiro[4.5]decane-7-carboxylate 
• 874360-01-7 benzyl [(1S,2R)-5-oxo-2-(2,4,5-trifluorophenyl)cyclohexyl]carbamate 
• 92138-20-0 natural Huperzine A 
• 916059-33-1 benzyl [(1S,2R,5S)-5-[2-(2-fluoroethoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate 
• 916059-22-8 benzyl [(1S,2R,5S)-5-[2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate 
• 916059-21-7 benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate 
• 916059-34-2 benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate 

Relevant articles and documents

Synthesis of the 4-azatricyclo[5.2.2.04,8]undecan-10-one core of Daphniphyllum alkaloid calyciphylline A using a Pd-catalyzed enolate alkenylation

(Chemical Equation Presented) The ABC ring system of the natural product calyciphylline A has been synthesized. The key steps were a palladium-catalyzed intramolecular coupling of an amino-tethered vinyl bromide with a ketone using potassium phenoxide as

Synthetic method of huperzine A

The invention belongs to the technical field of medicine synthesis and particularly relates to a synthetic method of huperzine A. The method includes twelve steps of reactions, 1,4-dioxaspiro[4.5]decan-8-one being a raw material, so that the chemical synthesis of the huperzine A is completed at a high total yield. The method is fewer in reaction steps, is simple in operations, has high yield, is stable in intermediates and gentle in reaction conditions, and is easy to control in reactions.

Iridium-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones: Enantioselective total synthesis of (-)-mesembrine

A highly efficient asymmetric hydrogenation of α-substituted α,β-unsaturated acyclic ketones catalyzed by chiral spiro iridium complexes for the preparation of chiral 2-substituted allylic alcohols has been developed (ee up to 99.7%). This method provides a concise route to (-)-mesembrine (34% yield, 12 steps).