2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol

Base Information

• Chemical Name: 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol
• CAS No.: 1104058-34-5
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 1104058-34-5.mol

Synonyms:2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol

Chemical Property of 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol

There total 5 articles about 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(S)-valinol (2026-48-4,473-75-6) + 3-methylhydroxy-benzonitrile (13589-71-4) → 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol (1104058-34-5)

Guidance literature:

With zinc(II) chloride; In chlorobenzene; at 131 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.07.070

Reference yield:

ortho-cresol (95-48-7,77504-84-8) → 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol (1104058-34-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tin(IV) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.33 h / 20 °C / Inert atmosphere

1.2: 8 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 0.33 h / 20 °C

3.1: dimethyl sulfoxide / 6 h / 100 °C

4.1: zinc(II) chloride / chlorobenzene / 72 h / 131 °C / Inert atmosphere

With hydroxylamine hydrochloride; tin(IV) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride; In dimethyl sulfoxide; chlorobenzene; toluene; 1.1: Casiraghi reaction / 1.2: Casiraghi reaction;

DOI:10.1016/j.tetlet.2011.07.070

Reference yield:

2-hydroxy-3-methylbenzaldehyde oxime (51673-93-9) → 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol (1104058-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 6 h / 100 °C

2: zinc(II) chloride / chlorobenzene / 72 h / 131 °C / Inert atmosphere

With zinc(II) chloride; In dimethyl sulfoxide; chlorobenzene;

DOI:10.1016/j.tetlet.2011.07.070

upstream raw materials:

(S)-valinol

3-methylsalicylic acid

2-methoxy-3-methylbenzaldehyde

3-methylhydroxy-benzonitrile