13589-71-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Methyl-6-cyano-phenol is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides. Its chemical properties make it a valuable component in the creation of these products.
Used in Corrosion Inhibition:
As a corrosion inhibitor, 2-Methyl-6-cyano-phenol helps protect materials from the damaging effects of corrosion, extending their lifespan and improving their performance in various applications.
Used in Dyes and Pigments Production:
2-Methyl-6-cyano-phenol is utilized as a component in the production of dyes and pigments, contributing to the coloration and stability of these products in different industries, such as textiles, plastics, and paints.
Safety Precautions:
Given its mild toxicity when ingested, it is crucial to handle 2-Methyl-6-cyano-phenol with care, using appropriate safety measures to minimize exposure and potential health risks.

InChI:InChI=1/C8H7NO/c1-6-3-2-4-7(5-9)8(6)10/h2-4,10H,1H3

Upstream product

• 95-48-7 ortho-cresol 
• 545-06-2 trichloroacetonitrile 
• 50-00-0 formaldehyd 
• 51673-93-9 2-hydroxy-3-methylbenzaldehyde oxime 
• 824-42-0 2-methoxy-3-methylbenzaldehyde 

Downstream Products

• 15777-70-5 4-hydroxy-3-methylbenzonitrile 
• 1104058-34-5 2-[(S)-4-isopropyl-4,5-dihydro-oxazol-2-yl]-6-methylphenol 
• 290347-99-8 3-Cyano-4-hydroxy-5-methylnitrobenzene 

Relevant academic research and scientific papers

Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening

Adenosine deaminase (ADA) is a human mononuclear Zn2+ metalloenzyme that converts adenosine to inosine. ADA is a validated drug target for cancer, but there has been little recent work on the development of new therapeutics against this enzyme. The lack of new advancements can be partially attributed to an absence of suitable assays for high-throughput screening (HTS) against ADA. To facilitate more rapid drug discovery efforts for this target, an in vitro assay was developed that utilizes the enzymatic conversion of a visibly emitting adenosine analogue to the corresponding fluorescent inosine analogue by ADA, which can be monitored via fluorescence intensity changes. Utilizing this assay, a library of ～350 small molecules containing metal-binding pharmacophores (MBPs) was screened in an HTS format to identify new inhibitor scaffolds against ADA. This approach yielded a new metal-binding scaffold with a Ki value of 26±1 μM.

Preparation method of substituted piperidine derivative

The invention discloses a preparation method of a substituted piperidine derivative 4(tert-butyl(2-(aminomethyl)-6-methylphenoxy)methyl)piperidine-1-carboxylate. The preparation method comprises the steps of carrying out oximation, elimination, etherifica

A general and convenient route to oxazolyl ligands

A diverse range of chiral and achiral oxazolyl ligands, which have many applications including catalysis and luminescent devices, are synthesized simply in three steps from readily available and inexpensive phenol and amino alcohol starting materials. The method can be applied to ligands with electron-donating/-withdrawing and sterically demanding/undemanding substituents, and can conveniently be scaled up to >25 g of product.

A one-pot synthesis of substituted salicylnitriles

Phenols were converted to salicylaldehydes with paraformaldehyde, MgCl2-Et3N in THF, and subsequent treatment with aqueous ammonia gave the corresponding imines which were oxidized with IBX to the desired salicylnitriles. The sequence of reactions was conveniently carried out as a one-pot procedure under mild conditions.

CARBAMOYL-TYPE BENZOFURAN DERIVATIVES

The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a cycloalkanediyl group, etc.; R4 and R5 are the same or different and each is an optionally substituted lower alkyl group, etc.; R1 is a halogen atom, etc.; Ring B of the formula: is an optionally substituted benzene ring; and R3 is a hydrogen atom, etc., or a pharmaceutically acceptable salt thereof, which is useful as an FXa inhibitor.

NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE

[From equivalent EP1710233A1] The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, arylalkenyl, aryloxy-lower alkyl, heteroaryl, heteroaryl-lower alkyl, etc; R3, R4, R5 and R6 are each hydrogen, halogen, cyano, lower alkyl, halo-lower alkyl, lower alkoxy, hydroxy, aryl, etc; provided that at least one of R3, R4, R5 and R6 is other than hydrogen. Compound (I) of the present invention shows a potent adenosine A2A receptor antagonistic activity, and are useful for treating or preventing a disease mediated by adenosine A2A receptors such as motor function disorders, depression, anxiety disorders, cognitive function disorders, cerebral ischemia disorders, restless legs syndrome and the like.

AROYLFURANES AND AROYLTHIOPHENES

The invention relates to compounds of formula (I) and of formula (II) wherein ring A is a phenyl, pyridine, pyrimidine or pyrazine ring, W and X are carbon or nitrogen, Y is oxygen or sulfur, R0 is different from hydrogen, Rx is -(C=O)R1 or cyano; R1 is hydrogen, optionally substituted hydroxy or optionally substituted amino, and the other substituents are as described in the specification. The invention further relates to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I) and of formula (II), to the use of compounds of formula (I) and of formula (II) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I), of formula (II) or of pharmaceutical compositions containing same.

BENZOFURAN DERIVATIVE

The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: -N="or" -CH=; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

Cyano containing oxamic acids and derivatives as thyroid receptor ligands

The present invention provides novel compounds of the Formula STR1and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R 1 -R 8 and X are as described herein. P

TEMPLATE HOUBEN-HOESCH REACTION ON METAL PHENOLATES. SYNTHESIS OF AROMATIC KETONES, NITRILES AND AMIDES. CRYSTAL STRUCTURE OF DICHLORO-BORON

The crystal structure of dichloro-boron (6dx) establishes for the first time the coordination mechanism of the ortho-selective reaction of metal phenolates and nitriles.Crystal data: chemical formula C9H7BCl5NO2; a = 11.743(2), b = 13.390(2), c = 8.765(3) Angstroem, β = 99.71(2) deg; space group P21/n.Variously substituted aromatic ketones, nitriles and amides have been obtained in a "one-pot" reaction.