4-Fluoro-4-phenylpiperidine hydrochloride

Base Information

• Chemical Name: 4-Fluoro-4-phenylpiperidine hydrochloride
• CAS No.: 1056382-25-2
• Molecular Formula: C11H15ClFN
• Molecular Weight: 215.698
• Hs Code.: 2933399990
• Mol file: 1056382-25-2.mol

Synonyms:4-Fluoro-4-phenylpiperidine hydrochloride;4-Fluoro-4-(3-phenylpropyl)piperidine hydrochloride

Chemical Property of 4-Fluoro-4-phenylpiperidine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.36560

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-4-phenylpiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-4-phenylpiperidine hydrochloride

There total 1 articles about 4-Fluoro-4-phenylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert‐butyl‐4‐fluoro‐4‐phenylpiperidine‐1‐carboxylate (400770-90-3) → 4-fluoro-4-phenylpiperidine hydrochloride (1056382-25-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 87.0%

4-bromo-1-butylpyridin-2(1H)-one (1127499-22-2) + 4-fluoro-4-phenylpiperidine hydrochloride (1056382-25-2) → 1'-butyl-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2-one (1127499-92-6)

Guidance literature:

With sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 16h;

Reference yield: 62.0%

4-fluoro-4-phenylpiperidine hydrochloride (1056382-25-2) + 2,4-dichloro-3-(trifluoromethyl)pyridine (1186194-98-8) → 2'-chloro-4-fluoro-4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl (1254981-31-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 110 ℃; for 4h; Sealed tube;

upstream raw materials:

tert‐butyl‐4‐fluoro‐4‐phenylpiperidine‐1‐carboxylate

Downstream raw materials:

1'-butyl-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2-one

2',3'-dichloro-4-fluoro-4-phenyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

2'-chloro-4-fluoro-4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-phenyl-4-fluoro-1-piperidinyl)methyl]-[1,2,4]triazolo[4,3-a]pyridine

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