2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

Base Information

Chemical Name:2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone
CAS No.:1093063-77-4
Molecular Formula:C₁₇H₁₄ClF₂N₃O
Molecular Weight:349.767
Hs Code.:

Synonyms:2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

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Chemical Property of 2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

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Technology Process of 2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

There total 6 articles about 2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1093063-76-3
5-fluoro-2-[2-fluoro-4-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-pyrimidine

: 79-04-9
chloroacetyl chloride

: 1093063-77-4
2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 136434-77-0
4-bromo-3-fluoroiodobenzene

: 1093063-77-4
2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.17 h

1.2: 80 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 80 °C

3.1: sodium carbonate / ethanol; water; toluene / 0.17 h

3.2: 90 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With potassium acetate; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1093063-74-1
4-(4-bromo-3-fluoro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1093063-77-4
2-chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 80 °C

2.1: sodium carbonate / ethanol; water; toluene / 0.17 h

2.2: 90 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With potassium acetate; sodium carbonate; triethylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;